Liposome Enhanced Detection of Amyloid Protein Aggregates
نویسندگان
چکیده
Thioflavin-T is used to image amyloid aggregates because of the excellent turn-on fluorescence properties, but binding affinities are low. By mounting multiple dye units on surface a vesicle, affinity for ?-synuclein fibrils increased by three orders magnitude, and optical response increased. Cooperative interactions headgroup lipid with protein provide general strategy construction multivalent probes based vesicles.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.0c03597